Alterations in Olfaction during Alzheimer Disease, Parkinson Disease and Lewy Body Disease
نویسندگان
چکیده
منابع مشابه
Alterations in Olfaction during Alzheimer Disease, Parkinson Disease and Lewy Body Disease
Increasing interest is being shown in the link between olfaction, a complex sensory system, and cognition, particularly in the elderly. Olfaction is known to affect cognitive abilities and mood. In this article, we consider the impairment of olfactory function due to Alzheimer disease (AD), Parkinson disease (PD) and Lewy body disease (LBD), through pathological changes in the peripheral and ce...
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Cortical Lewy body disease as a cause of dementia has been recognized for more than 40 years. Only in the past 15 to 20 years, however, has the true frequency of this entity come to be appreciated, primarily because of the advent of sensitive and specific immunohistochemical diagnostic techniques. We now know that there is frequent and extensive overlap, both clinically and pathologically, betw...
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BACKGROUND The significance of Lewy bodies detected at autopsy in the brains of clinically normal individuals is uncertain but may represent preclinical Parkinson disease (PD). OBJECTIVE To determine whether diminished striatal dopaminergic innervation and nigral cell loss are present in incidental Lewy body disease (iLBD), as one might expect if it is a forerunner of PD. DESIGN Case-contro...
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Several components of Lewy bodies have been identified, but the precise mechanism responsible for the formation of Lewy bodies remains undetermined. The 14-3-3 protein family is involved in numerous signal transduction pathways and interacts with alpha-synuclein, which is a major constituent of Lewy bodies. To elucidate the role of 14-3-3 proteins in neuro-degenerative disorders associated with...
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The objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropatholog...
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ژورنال
عنوان ژورنال: Journal of Alzheimer’s Disease & Parkinsonism
سال: 2016
ISSN: 2161-0460
DOI: 10.4172/2161-0460.1000274